Inverse spectroscopic optical coherence tomography (IS-OCT) for characterization of particle size and concentration

Inverse spectroscopic optical coherence tomography (IS-OCT) methods apply inverse problem formulations to acquired spectra estimate depth-resolved sample properties. In the current study, we modelled time-frequency-distributions using Lambert-Beer’s law and implemented IS-OCT backscattering calculated from Mie theory, then demonstrated algorithm on polystyrene microspheres under idealized conditions. The results are significant because method generates depth dependent estimates of both concentration diameter scattering particles.